The latter is further supported by recent single molecule imaging studies. These data imply that the stress granule transcriptome is influenced the valency of RNA (for proteins or other RNAs) and by the rates of RNA run-off from polysomes. Įfforts to identify all RNAs within stress granules (the stress granule transcriptome) in an unbiased way by sequencing RNA from biochemically purified stress granule "cores" have shown that RNAs are not recruited to stress granules in a sequence-specific manner, but rather generically, with longer and/or less-optimally translated transcripts being enriched. Conversely, it has also been argued that stress granules are not important sites for mRNA storage nor do they serve as an intermediate location for mRNAs in transit between a state of storage and a state of degradation. Molecules can go down one of three paths: further storage, degradation, or re-initiation of translation. Stress granules might also function as a decision point for untranslated mRNAs. The accumulation of RNAs into dense globules could keep them from reacting with harmful chemicals and safeguard the information coded in their RNA sequence. Stress granules have long been proposed to have a function to protect RNAs from harmful conditions, thus their appearance under stress. The function of stress granules remains largely unknown. 4 Protein composition of stress granules.2.1 Potential roles of RNA-RNA interactions.
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